Supplementation with Spirulina platensis Modulates Aortic Vascular Reactivity through Nitric Oxide and Antioxidant Activity. (24th October 2019)

• Record Type: Journal Article
• Authors: de Freitas Brito, Aline; Silva, Alexandre Sérgio; de Souza, Alesandra Araújo; Ferreira, Paula Benvindo; de Souza, Iara Leão Luna; da Cunha Araujo, Layanne Cabral; da Silva Félix, Gustavo; de Souza Sampaio, Renata; da Conceição Correia Silva, Maria; Tavares, Renata Leite; de Andrade Pereira, Reabias; Neto, Manoel Miranda; Silva, Bagnólia Araújo
• Other Names: Carrizzo Albino Guest Editor.
• Is Part Of: Oxidative medicine and cellular longevity. Volume 2019(2019)
• Publication Date: 2019-10-24
• Subjects: Oxidative stress -- Periodicals; Cells -- Aging -- Periodicals; Cells -- Aging; Oxidative stress; Oxidative Stress -- Periodicals; Cell Aging -- Periodicals; Periodicals; 611.0181
• DOI: 10.1155/2019/7838149
• Languages: English
• ISSNs: 1942-0900

Abstract

Abstract : The possible mechanism is involved in the effects of Spirulina platensis on vascular reactivity. Animals were divided into sedentary group (SG) and sedentary groups supplemented with S. platensis at doses of 50 (SG50), 150 (SG150), and 500 mg/kg (SG500). To evaluate reactivity, cumulative concentration-response curves were constructed for phenylephrine and acetylcholine. To evaluate the involvement of the nitric oxide (NO) pathway, aorta tissue was preincubated with L-NAME and a new curve was then obtained for phenylephrine. Biochemical analyses were performed to evaluate nitrite levels, lipid peroxidation, and antioxidant activity. To contractile reactivity, only SG500 (p D 2 = 5.6 ± 0.04 vs. 6.1 ± 0.06, 6.2 ± 0.02, and 6.2 ± 0.04 ) showed reduction in phenylephrine contractile potency. L-NAME caused a higher contractile response to phenylephrine in SG150 and SG500. To relaxation, curves for SG150 (p D 2 = 7.0 ± 0.08 vs. 6.4 ± 0.06 ) and SG500 (p D 2 = 7.3 ± 0.02 vs. 6.4 ± 0.06 ) were shifted to the left, more so in SG500. Nitrite was increased in SG150 and SG500. Lipid peroxidation was reduced, and oxidation inhibition was increased in all supplemented groups, indicating enhanced antioxidant activity. Chronic supplementation with S. platensis (150/500 mg/kg) caused a decrease in contractile response and increase in relaxation and nitrite levels, indicating greater NO production, due to decreased oxidative stress and increased antioxidant activity.