Accuracy Evaluation of Circular RNA in Diagnosing Lung Cancer in a Chinese Population. (20th October 2019)

• Record Type: Journal Article
• Authors: Xiao, Zhihao; Chen, Xinglei; Lu, Xiaodan; Zhong, Xuexin; Ling, Yihui
• Other Names: Nicolazzo Chiara Academic Editor.
• Is Part Of: Disease markers. Volume 2019(2019)
• Publication Date: 2019-10-20
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2019/7485389
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Circular RNA (circRNA) is a class of recently discovered noncoding RNA. circRNAs can be used as a potent noninvasive biological marker of cancer owing to their varying expression levels among different cancers. This meta-analysis was performed to assess the accuracy of circRNAs in diagnosing lung cancer. A total of eight studies identified through searching the PubMed, Web of Science, Cochrane Library, and Embase from inception to March 20, 2019 were eligible for this meta-analysis. The pooled sensitivity, specificity, positive likelihood ratios, negative likelihood ratios, and diagnostic odds ratio were 0.77 (95% confidence interval (CI): 0.73–0.80; I 2 = 8.98 % ), 0.76 (95% CI: 0.69–0.82; I 2 = 63.12 % ), 3.17 (95% CI: 2.43–4.14; I 2 = 33.18 % ), 0.31 (95% CI: 0.26–0.37; I 2 = 20.36 % ), and 10.26 (95% CI: 6.87–15.31; I 2 = 97.18 % ), respectively. The area under the receiver operating characteristic curve was 0.78 (95% CI: 0.74–0.81). The study confirmed the use of circRNAs in diagnosing lung cancer in a Chinese population.