(-)-Calcaridine B, a new chiral aminoimidazole-containing alkaloid from the marine sponge Leucetta chagosensis. Issue 11 (2nd November 2019)

• Record Type: Journal Article
• Authors: Tang, Wei-Zhuo; Yang, Zhong-Zhen; Sun, Fan; Wang, Shu-Ping; Yang, Fan; Jiao, Wei-Hua; Lin, Hou-Wen
• Is Part Of: Journal of Asian natural products research. Volume 21:Issue 11(2019)
• Page Start: 1123
• Page End: 1128
• Publication Date: 2019-11-02
• Subjects: Marine sponge -- Leucetta chagosensis -- chiral imidazole alkaloid -- cytotoxicities; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2018.1499729
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: LC-DAD/MS-based dereplication of organic extract of a calcareous sponge Leucetta chagosensis afforded one new chiral aminoimidazole-containing alkaloid, (-)-calcaridine B (1 ), along with one achiral imidazole analog leucettamine E (2 ) as well as one known imidazole derivative (2 E, 9 E )-pyronaamidine-9-( N -methylimine) (3 ). Their structures were elucidated on the basis of NMR spectroscopic analyses, and comparing with the literature. The cytotoxic activities of all isolates were evaluated against three human cancer cell lines, and compounds 1 and 3 exhibited mild cytotoxicities toward the MCF-7 cell line with IC50 values of 25.3–24.2 μ M, respectively. Graphical Abstract: