Direct amide synthesis via Ni-mediated aminocarbonylation of arylboronic acids with CO and nitroarenes. Issue 91 (28th October 2019)

• Record Type: Journal Article
• Authors: Shen, Ni; Cheung, Chi Wai; Ma, Jun-An
• Is Part Of: Chemical communications. Volume 55:Issue 91(2019)
• Page Start: 13709
• Page End: 13712
• Publication Date: 2019-10-28
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc06638a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Ni metal-mediated aminocarbonylation based on readily available arylboronic acids, nitroarenes, and carbon monoxide was achieved to prepare a variety of aryl amides. Abstract : Herein we describe an alternative and unconventional approach of an aminocarbonylation reaction to access aryl amides from readily available and low-cost arylboronic acids and nitroarenes. Nickel metal can serve as both reductant and catalyst in this direct aminocarbonylation. This protocol exhibits a good functional group compatibility and allows a variety of aryl amides to be synthesized, including several drug-like molecules.