Radiosynthesis and preliminary in vivo evaluation of 18F-labelled glycosylated duramycin peptides for imaging of phosphatidylethanolamine during apoptosis. Issue 11 (25th September 2019)

• Record Type: Journal Article
• Authors: Haskali, Mohammad B.; Denoyer, Delphine; Roselt, Peter D.; Hicks, Rodney J.; Hutton, Craig A.
• Is Part Of: MedChemComm. Volume 10:Issue 11(2019)
• Page Start: 1930
• Page End: 1934
• Publication Date: 2019-09-25
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c9md00354a
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : [ 18 F]-Labelled duramycin derivatives incorporating hydrophilic aminogalacturonic acid moieties were prepared as tracers for in vivo imaging of phosphatidylethanolamine during apoptosis. Abstract : Duramycin derivatives incorporating an [ 18 F]-labelled prosthetic group and one or two hydrophilic sugar amino acid moieties have been prepared as potential tracers for imaging of phosphatidylethanolamine during apoptosis. [ 18 F]FP-digalacto-duramycin exhibited a low Log D, high renal clearance and low background activity and is a promising radiotracer for tracking apoptosis in vivo .