Different solid forms for optimizing route of administration of the herpes drug Pritelivir. Issue 11 (9th September 2019)

• Record Type: Journal Article
• Authors: Ruebsamen-Schaeff, Helga; Buschmann, Helmut
• Is Part Of: MedChemComm. Volume 10:Issue 11(2019)
• Page Start: 1867
• Page End: 1870
• Publication Date: 2019-09-09
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c9md00233b
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : In depth knowledge of the physicochemical properties of different salt forms and respective solvates/hydrates has a significant impact on the pharmaceutical dosage form. Abstract : Pritelivir (AIC316, BAY 57-1293) was discovered as a highly potent drug against herpes simplex viruses with a novel mode of action, i.e. inhibition of the viral helicase–primase. A side by side comparison of the oral form against Valtrex™ in patients with genital herpes, showed superiority in phase II testing for Pritelivir. A number of different solid forms have been generated for additional, e.g. systemic, or topical applications.