A non-enzymatic glucose sensor with enhanced anti-interference ability based on a MIL-53(NiFe) metal–organic framework. Issue 44 (18th October 2019)

• Record Type: Journal Article
• Authors: Zhang, Li; Ma, Xiaoni; Liang, Hongbo; Lin, Huihui; Zhao, Guangyu
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 44(2019)
• Page Start: 7006
• Page End: 7013
• Publication Date: 2019-10-18
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb01832h
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : The MIL-53(NiFe) MOF was used as a molecular sieve to improve the anti-interference ability in glucose detection. Abstract : Non-enzymatic glucose sensors are attracting significant attention owing to their low cost, storage convenience and reusability; however, their poor anti-interference caused by their weak selectivity towards glucose limits their practicability. In the present study, a MIL-53(NiFe) metal–organic framework (MOF) was prepared on Ni foam to serve as a self-supported electrode for non-enzymatic glucose detection. Due to the abundant active sites in the MIL-53(NiFe) MOF and its good stability in an alkaline solution, the sensors exhibited a high sensitivity (41.95 mA mM −1 cm −2 ) and a low detection limit (0.67 μM). Moreover, the molecular sieve effect of the MIL-53(NiFe) MOF led to a remarkable anti-interference ability, even at the interference concentrations of up to 20% glucose, a higher value than that in human serum. In addition, a heat treatment was carried out to remove the residual terephthalic acid in the MOF tunnels, and this promoted the detection linear range to 2–1600 μM. The reusability, reproducibility and long-term stability of the sensors were also studied, and the results implied good practicability of the MIL-53(NiFe) MOF-based sensors. Furthermore, the good practicability of the sensors was verified by testing human serum samples. The results showed the relative standard deviation of 2.73% from the hospital results, and the standard recovery was nearly 100%.