Decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides. Issue 43 (22nd October 2019)

• Record Type: Journal Article
• Authors: Shang, Jia-Qi; Wang, Xiang-Xiang; Xin, Yangchun; Li, Yi; Zhou, Bin; Li, Ya-Min
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 43(2019)
• Page Start: 9447
• Page End: 9455
• Publication Date: 2019-10-22
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob02023c
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides delivering carbonyl-containing pyrido[4, 3, 2- gh ]phenanthridines is presented. Abstract : An oxidative decarboxylative cascade cyclization of α-keto acids with 2-cyano-3-arylaniline-derived acrylamides was developed. This cascade reaction exhibits a broad substrate scope, and provides an efficient access to carbonyl-containing pyrido[4, 3, 2- gh ]phenanthridines. A possible mechanism is proposed.