Non-lethal growth inhibition by arresting the starch utilization system of clinically relevant human isolates of Bacteroides dorei. Issue 11 (12th July 2019)

• Record Type: Journal Article
• Authors: Santilli, Anthony D.; Russell, Jordan T.; Triplett, Eric W.; Whitehead, Kristi J.; Whitehead, Daniel C.
• Is Part Of: MedChemComm. Volume 10:Issue 11(2019)
• Page Start: 1875
• Page End: 1880
• Publication Date: 2019-07-12
• Subjects: Pharmaceutical chemistry -- Periodicals; 615.19
• DOI: 10.1039/c9md00301k
• Languages: English
• ISSNs: 2040-2503

Abstract

Abstract : Acarbose elicits potent, non-microbicidal growth inhibition of clinically relevant Bacteroides dorei strains by arresting the starch utilization system. Abstract : We describe the inhibition of the starch utilization system (Sus) belonging to various strains of Bacteroides dorei in a non-lethal manner using the small molecule probe, acarbose. Concentrations of acarbose as low as 5 μM significantly impede the growth of B. dorei and increase the doubling time of cultures. The successful inhibition of this species of Bacteroides is relevant to several disease states including type I diabetes mellitus. This method continues to explore a new, potential route to intervene in illnesses associated with aberrant changes in the composition of the human gut microbiota through the strategic manipulation of its constituents.