EDA complex directed N-centred radical generation from nitrosoarenes: a divergent synthetic approach. Issue 90 (28th October 2019) - Ghosh, Soumen
Abstract : N-Centred radicals generated via the formation of EDA complexes are added to electron-deficient allylsulfones to produce isoxazolidines, aziridines or β-amino acid derivatives. Abstract : A metal-free strategy for the generation of N-centred radicals from nitrosoarenes (activated by allylsulfones) via electron donor–acceptor (EDA) complexes is reported. The EDA complex initiates a single electron transfer (SET) process via diisopropylethylamine (iPr2 NEt) or a Hantzsch ester (HE). This mild and operationally simple protocol, initiated by the formation of a C–N bond, can conclude to either isoxazolidine or aziridine derivatives or can result in β-amino acid derivatives.