AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release. Issue 60 (29th October 2019)

• Record Type: Journal Article
• Authors: Zhou, Lu; Liu, Guojie; Wang, Yang; Liu, Jianling; Zhang, Yajie; Ma, Yong
• Is Part Of: RSC advances. Volume 9:Issue 60(2019)
• Page Start: 34958
• Page End: 34962
• Publication Date: 2019-10-29
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra07404j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release. Abstract : In order to improve drug efficacy, and reduce drug toxicity and side effects, a novel drug controlled release system was developed based on mesoporous silica nanoparticles (MSNs) with gold nanoparticles (AuNPs) acting as pore caps and short single-stranded DNA (ssDNA) oligomers as the linker. The synthesised composites were characterized by Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), zeta potential measurement, transmission electron microscopy (TEM) and UV-vis spectroscopy. The anticancer drug doxorubicin (Dox) was applied as a model drug to investigate the 808 nm near infrared (NIR) laser-controlled drug release behavior at different pH by fluorescence measurements. The investigation results demonstrate that this nanocarrier could achieve drug controlled release by external near-infrared (NIR) laser stimulation, which is expected to be applied in cancer therapy.