Association between plasma concentration of copper and gestational diabetes mellitus. Issue 6 (December 2019)

• Record Type: Journal Article
• Authors: Li, Peiyun; Yin, Jiawei; Zhu, Yalun; Li, Shuzhen; Chen, Sijing; Sun, Taoping; Shan, Zhilei; Wang, Jiawei; Shang, Qianqian; Li, Xiaoqin; Yang, Wei; Liu, Liegang
• Is Part Of: Clinical nutrition. Volume 38:Issue 6(2019)
• Page Start: 2922
• Page End: 2927
• Publication Date: 2019-12
• Subjects: Copper -- Gestational diabetes mellitus -- Case-control study -- Pregnancy; AGE advanced glycation end-product -- BMI body mass index -- CI confidence interval -- Cu copper -- FPG fasting plasma glucose -- FPI fasting plasma insulin -- GDM gestational diabetes mellitus -- HDL-C high-density lipoprotein cholesterol -- HOMA homeostasis model assessment -- IQR interquartile range -- IR insulin resistance -- LDL-C low-density lipoprotein cholesterol -- OGTT oral glucose tolerance test -- OR odds ratio -- ROS reactive oxygen species -- SOD superoxide dismutase -- SD standard deviation -- TC total cholesterol -- TG triglycerides; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2018.12.032
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Emerging findings have raised concerns about significant associations between excessive copper (Cu) and abnormal glucose metabolism. Nevertheless, related researches on the relationship of Cu concentration and gestational diabetes mellitus (GDM) are limited. The objective of this study was to determine whether plasma Cu concentration is associated with GDM. Methods: A case–control study of 248 cases of GDM and 248 age-, parity- and gestational age-matched controls was conducted in Wuhan, China between August 2012 and April 2015. Fasting blood samples of participants were collected at the time of GDM screening (≥24 weeks of gestation). Plasma Cu concentrations were detected by inductively coupled plasma mass spectrometry. The strength of the association of plasma Cu with GDM odds was evaluated by odds ratios (ORs) with 95% confidence intervals (CIs) from conditional logistic regression. Partial Spearman or Pearson correlation coefficients were calculated to estimate the interrelationship between plasma Cu and the risk factors of GDM. Results: Plasma Cu concentrations in the GDM group (mean ± SD: 1960.24 ± 391.98 μg/L) were higher than in the control group (mean ± SD: 1842.43 ± 387.09 μg/L) ( P = 0.001). After adjustment for possible confounders, the ORs (95% CIs) of GDM across increasing quartiles of plasma Cu levels were 1.00 (referent), 1.79 (0.90–3.55), 2.72 (1.35–5.48) and 2.91 (1.48–5.75), respectively; the OR (95% CI) of GDM was 1.33 (1.06–1.67) for each standard deviation increment of plasma Cu. Moreover, Cu concentrations were positively associated with fasting plasma glucose, 1-h post-glucose load and 2-h post-glucose load (all P < 0.05). Conclusions: The present study indicated a significantly increased odds of GDM in association with higher concentrations of plasma Cu. Prospective cohort studies in other populations are needed to confirm our findings.