0758 Natural History of Insomnia Symptoms from Childhood through Adolescence into Young Adulthood: The Penn State Child Cohort. (12th April 2019)

• Record Type: Journal Article
• Authors: Fernandez-Mendoza, Julio; Calhoun, Susan L; Puzino, Kristina; Danisi, Jacqueline M; He, Fan; Liao, Jason; Liao, Duanping; Vgontzas, Alexandros N; Bixler, Edward O
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A304
• Page End: A305
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.756
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Difficulties falling and/or staying asleep (DFA/DSA) are the most common parent-reported symptoms of poor sleep in children, while insomnia is the most prevalent sleep disorder in adults. However, little is known about the natural history of childhood and adolescent poor sleep and insomnia in their transition to young adulthood. Methods: The Penn State Child Cohort is a general population sample of 700 children (8.7±1.7y), of whom 421 were followed-up 8.3 years later during adolescence (17.0±2.3y) and 302 another 6.6 years later during young adulthood (23.6±2.6y). Subjects underwent a 9-h polysomnography in childhood and adolescence and parent- or self-reported standardized surveys at all time points. Poor sleep was defined as moderate-to-severe parent-reported (childhood) or self-reported (adolescence and young adulthood) DFA/DSA, while the presence of insomnia was also ascertained in young adulthood. Results: Among youth without any history of poor sleep, the incidence rates of poor sleep and insomnia in young adulthood were 18.0% and 6.3%, respectively. The remission rates of poor sleep in young adulthood were similar in children who had remitted in adolescence (56.0%) and those with adolescent-onset poor sleep (50.0%), while significantly lower (29.6%) in adolescents with childhood-onset poor sleep (P<0.05). The incidence rate of insomnia in young adulthood was significantly increased (P<0.05) in youth with a history of poor sleep, regardless of whether it was childhood-onset (18.5%), adolescent-onset (18.8%) or had remitted in the transition to adolescence (16.0%). Conclusion: This ongoing 15-year longitudinal study with three time points shows that childhood-onset insomnia symptoms that persist into adolescence are highly unlikely to remit in the transition to young adulthood, a low remission rate (25-30%) similar to that found in middle-age adults. Interestingly, worsening into insomnia in young adulthood was not associated with an earlier, childhood-onset of insomnia symptoms. Support (If Any): NIH (R01 HL136587, R01 HL63772, R01 HL97165, UL1 TR000127, C06 RR16499)