0542 Delta power in Obstructive Sleep Apnea with predominant Respiratory Effort Related Arousals before and after therapy with Continuous Positive Airway Pressure. (12th April 2019)

• Record Type: Journal Article
• Authors: Monegro, Alberto F; Sahota, Pradeep K; Bollu, Pradeep C; Thakkar, Manesh F
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A216
• Page End: A217
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.540
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: High amplitude delta waves in electroencephalography have been studied as a correlate to sleep intensity. An increase in delta power has been observed in patients during recovery sleep after sleep deprivation. The significance of delta power however has not been well studied in patients with obstructive sleep apnea (OSA) before and/or after therapy with Continuous Positive Airway Pressure (CPAP). This report aims to study the delta power in patients with OSA with predominant Respiratory Effort Related Arousals (RERAs) with an apnea-hypopnea index (AHI) of less than 5. Methods: We thus far have identified 524 patients with baseline polysomnograms performed from May 2016 to November 2018. Of these patients, 135 were found to have AHI < 5 and a Respiratory Disturbance Index (RDI) of at least 5 or greater. Spectral band power was calculated for the following frequency ranges: delta (1- 4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz). Relative delta power was calculated from the longest period of N3 in the initial 4 hours of sleep using C3-M2 and C4-M1 derivations. Results: Initial analysis was performed in 10 patients. 5 patients with RDI < 10 had (Mean ± SEM) age of 45.6 (±14.6); BMI of 30.3 (±5.9), Epworth Sleepiness Scale (ESS) of 12.4 (±6.2), AHI of 3.0 (±1), and RDI of 6.5 (±0.5). 5 patients with RDI ≥ 10, had (Mean ± SEM) age of 41.2 (± 14.5), BMI of 35.6 (±10.9), ESS of 10.4 (±3.1), AHI of 2.8 (±1.3), and RDI of 20.7 (±6.3). In patients with RDI < 10, the average change in delta power was 1.13% and those with RDI ≥ 10 was -10.32%. 7 patients reported subjective improvement in quality of sleep, but this did not correlate with change in delta power. Statistical analysis will be performed after gathering data from a larger sample size. Conclusion: There was an overall decrease in delta power in patients with a higher RDI. Support (If Any)