Biosynthesis and regulation mechanisms of the Pasteurella multocida capsule. (December 2019)

• Record Type: Journal Article
• Authors: Guan, Lijun; Xue, Yun; Ding, Wenwen; Zhao, Zhanqin
• Is Part Of: Research in veterinary science. Volume 127(2019)
• Page Start: 82
• Page End: 90
• Publication Date: 2019-12
• Subjects: Pasteurella multocida -- Capsule -- Glycosaminoglycan -- Biosynthesis -- Expression regulation; Veterinary medicine -- Periodicals; Veterinary Medicine -- Periodicals; Médecine vétérinaire -- Périodiques; Médecine vétérinaire -- Recherche -- Périodiques; Diergeneeskunde; 636.089
• DOI: 10.1016/j.rvsc.2019.10.011
• Languages: English
• ISSNs: 0034-5288

Abstract

Abstract: Pasteurella multocida possesses a polysaccharide capsule composed of a viscous surface layer that acts as a critical structural component and virulence factor. Capsular polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immunological mechanism for bacterial molecular mimicry, resistance to phagocytosis, and immune evasion during the infection process. In recent years, a series of important research advances have been made in understanding the biosynthesis and regulatory aspects of the P. multocida capsule. This review systematically examines the serogroups, polysaccharide composition and structures, biosynthetic loci and functions, biosynthesis pathways, and expression regulation mechanisms of the P. multocida capsule, supplying a theoretical basis for the molecular pathogenesis of the P. multocida capsule and the future development of capsular polysaccharide vaccines. Highlights: P. multocida is a typical capsular bacterium, and its capsule is an essential structural component and pathogenic factor. Capsule polysaccharides are structurally similar to vertebrate glycosaminoglycans, providing an immune evasion mechanism. This review summarizes the serogroups, biosynthetic loci and expression regulation mechanism of the P. multocida capsule.