Cover Feature: Strong Binding and Off–On Signaling Functions of Deep‐Red Fluorescent TO‐PRO‐3 for Influenza A Virus RNA Promoter Region (ChemBioChem 21/2019). (22nd October 2019)

• Record Type: Journal Article
• Authors: Sato, Yusuke; Aiba, Yuri; Yajima, Sayaka; Tanabe, Takaaki; Higuchi, Kei; Nishizawa, Seiichi
• Is Part Of: Chembiochem. Volume 20:Number 21(2019)
• Page Start: 2684
• Page End: 2684
• Publication Date: 2019-10-22
• Subjects: drug discovery -- dyes/pigments -- fluorescence -- RNA -- viruses; Biochemistry -- Periodicals; Molecular biology -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1002/cbic.201900621
• Languages: English
• ISSNs: 1439-4227

Abstract

Abstract : The cover feature picture shows the deep‐red emission of TO‐PRO‐3, a thiazole orange analogue with a trimethine bridge, that can strongly and selectively bind to the internal loop structure of the influenza A virus RNA promoter region. TO‐PRO‐3 was shown to be a useful fluorescence indicator for assessing the binding capabilities of various test compounds for this RNA region, with a view to developing anti‐influenza drug candidates. More information can be found in the communication by S. Nishizawa et al. on page 2752 in Issue 21, 2019 (DOI: 10.1002/cbic.201900331 ).