Effect of population stratification on SNP‐by‐environment interaction. Issue 8 (20th August 2019)

• Record Type: Journal Article
• Authors: An, Jaehoon; Won, Sungho; Lutz, Sharon M.; Hecker, Julian; Lange, Christoph
• Is Part Of: Genetic epidemiology. Volume 43:Issue 8(2019)
• Page Start: 1046
• Page End: 1055
• Publication Date: 2019-08-20
• Subjects: genetic association -- population stratification -- SNP‐by‐environment interaction; Genetic epidemiology -- Periodicals; Heredity -- Periodicals; Medical geography -- Periodicals; 614
• DOI: 10.1002/gepi.22250
• Languages: English
• ISSNs: 0741-0395

Abstract

Abstract: Proportions of false‐positive rates in genome‐wide association analysis are affected by population stratification, and if it is not correctly adjusted, the statistical analysis can produce the large false‐negative finding. Therefore various approaches have been proposed to adjust such problems in genome‐wide association studies. However, in spite of its importance, a few studies have been conducted in genome‐wide single nucleotide polymorphism (SNP)‐by‐environment interaction studies. In this report, we illustrate in which scenarios can lead to the false‐positive rates in association mapping and approach to maintaining the overall type‐1 error rate.