A first report of porphyria cutanea tarda successfully treated with glycyrrhizin. Issue 5 (15th July 2019)

• Record Type: Journal Article
• Authors: Li, Ying; Yu, Ning; Han, Dandan; Ding, Yangfeng; Xu, Yueming
• Is Part Of: Dermatologic therapy. Volume 32:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-15
• Subjects: glycyrrhizin -- Porphyria cutanea tarda -- skin lesion -- treatment; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/dth.13014
• Languages: English
• ISSNs: 1396-0296

Abstract

Abstract: Porphyria cutanea tarda (PCT) is a condition that affects liver and skin by reduction of hepatic uroporphyrinogen decarboxylase activity. It is characterized by blistering lesions, erosions and crusts on sun‐exposed areas. We report a 51‐year‐old male presenting with recurrent episodes of bullae, erosions, and crust on his neck and dorsum of the hands for 3 months. Aspartate aminotransferase, alanine aminotransferase, gamma‐glutamyl transferase, alkaline phosphatase, lactate dehydrogenase levels, as well as total plasma porphyrin and urinary uroporphyrin levels were elevated. Based on the clinical manifestations, the history and laboratory findings, a diagnosis of PCT was made. The cutaneous and biochemical abnormalities of the patient improved with therapy of glycyrrhizin.