Racial/ethnic disparities in renal cell carcinoma: Increased risk of early‐onset and variation in histologic subtypes. (11th September 2019)

• Record Type: Journal Article
• Authors: Batai, Ken; Harb‐De la Rosa, Alfredo; Zeng, Jiping; Chipollini, Juan J.; Gachupin, Francine C.; Lee, Benjamin R.
• Is Part Of: Cancer medicine. Volume 8:Number 15(2019:Nov.)
• Page Start: 6780
• Page End: 6788
• Publication Date: 2019-09-11
• Subjects: American Indians -- early onset -- health disparities -- Hispanic Americans -- renal cell carcinoma subtypes; 616.994005
• DOI: 10.1002/cam4.2552
• Languages: English
• ISSNs: 2045-7634

Abstract

Abstract: Background: Racial/ethnic minority groups have a higher burden of renal cell carcinoma (RCC), but RCC among Hispanic Americans (HAs) and American Indians and Alaska Natives (AIs/ANs) are clinically not well characterized. We explored variations in age at diagnosis and frequencies of RCC histologic subtypes across racial/ethnic groups and Hispanic subgroups using National Cancer Database (NCDB) and Arizona Cancer Registry Data. Methods: Adult RCC cases with known race/ethnicity were included. Logistic regression analysis was performed to estimate odds and 95% confidence interval (CI) of early‐onset (age at diagnosis <50 years) and diagnosis with clear cell RCC (ccRCC) or papillary RCC. Results: A total of 405 073 RCC cases from NCDB and 9751 cases from ACR were identified and included. In both datasets, patients from racial/ethnic minority groups had a younger age at diagnosis than non‐Hispanic White (NHW) patients. In the NCDB, AIs/ANs had twofold increased odds (OR, 2.21; 95% CI, 1.88‐2.59) of early‐onset RCC compared with NHWs. HAs also had twofold increased odds of early‐onset RCC (OR, 2.14; 95% CI, 1.79‐2.55) in the ACR. In NCDB, ccRCC was more prevalent in AIs (86.3%) and Mexican Americans (83.5%) than NHWs (72.5%). AIs/ANs had twofold increased odds of diagnosis with ccRCC (OR, 2.18; 95% CI, 1.85‐2.58) in the NCDB, but the association was stronger in the ACR (OR, 2.83; 95% CI, 2.08‐3.85). Similarly, Mexican Americans had significantly increased odds of diagnosis with ccRCC (OR, 2.00; 95% CI, 1.78‐2.23) in the NCDB. Conclusions: This study reports younger age at diagnosis and higher frequencies of ccRCC histologic subtype in AIs/ANs and Hispanic subgroups. These variations across racial/ethnic groups and Hispanic subgroups may have potential clinical implications. Abstract : Renal cell carcinoma patients from racial/ethnic minority groups have increased risk of diagnosis at a younger age than non‐Hispanic White patients