Cover Feature: Pep‐Lipid Cubosomes and Vesicles Compartmentalized by Micelles from Self‐Assembly of Multiple Neuroprotective Building Blocks Including a Large Peptide Hormone PACAP‐DHA (ChemNanoMat 11/2019). Issue 11 (10th October 2019)

• Record Type: Journal Article
• Authors: Angelova, Angelina; Drechsler, Markus; Garamus, Vasil M.; Angelov, Borislav
• Is Part Of: ChemNanoMat. Volume 5:Issue 11(2019)
• Page Start: 1337
• Page End: 1337
• Publication Date: 2019-10-10
• Subjects: BioSAXS -- cryo-TEM -- cubosome -- lipidated peptide hormone (class B GPCR ligand) -- multicompartment nanostructure; Nanochemistry -- Periodicals; Nanostructured materials -- Periodicals; Nanochemistry; Nanostructured materials; Periodicals; 541.2
• DOI: 10.1002/cnma.201900548
• Languages: English
• ISSNs: 2199-692X

Abstract

Abstract : Compartmentalized liquid crystalline nanostructures embedding a class B GPCR ligand pituitary adenylate cyclase‐activating polypeptide (PACAP), which is modified by an ω‐3 polyunsaturated fatty acid DHA, are obtained in a two‐fold approach by co‐assembly of the lipidated peptide hormone with multiple neuroprotective compounds. The performed synchrotron small‐angle X‐ray scattering (BioSAXS) and cryo‐TEM studies evidenced the formation of (i) intriguing compartmentalized vesicles enclosing nanopatterns of pep‐lipid micelles and (ii) pep‐lipid cubosomes of core‐shell organizations. More information can be found in the Full Paper by Angelina Angelova et al. on page 1381 in Issue 11, 2019 (DOI: 10.1002/cnma.201900468 ).