Prognostic value of blood and lymphatic vessel markers in tongue cancer: A systematic review. Issue 11 (30th September 2019)

• Record Type: Journal Article
• Authors: Almahmoudi, Rabeia; Kasanen, Merimaija; Sieviläinen, Meri; Salem, Abdelhakim; Pirinen, Matti; Salo, Tuula; Al‐Samadi, Ahmed
• Is Part Of: Cancer science. Volume 110:Issue 11(2019)
• Page Start: 3424
• Page End: 3433
• Publication Date: 2019-09-30
• Subjects: biomarker -- blood microvessel density -- lymphatic vessel density -- prognosis -- tongue squamous cell carcinoma; Cancer -- Periodicals; Neoplasms -- Periodicals; Research -- Periodicals; Electronic journals; 616.994005
• DOI: 10.1111/cas.14189
• Languages: English
• ISSNs: 1347-9032

Abstract

Abstract: Tongue squamous cell carcinoma (TSCC) has a poor prognosis due to its early metastasis through blood and lymphatic vessels. We undertook a systematic review to investigate the prognostic significance of blood microvessel density (MVD) and lymphatic vessel density (LVD) in TSCC patients. We carried out a systematic search in Ovid Medline, Scopus, and Cochrane libraries. All studies that evaluated the prognostic significance of MVD/LVD markers in TSCC were systematically retrieved. Our results showed that MVD/LVD markers, CD31, CD34, CD105, factor VIII, lymphatic vessel endothelial hyaluronan receptor‐1, and D2‐40 were evaluated in TSCC patients until 28 June 2018. Six out of 13 studies reported markers that were associated with poor prognosis in TSCC. Two out of three studies suggested that a high number of D2‐40 + vessels predicated low overall survival (OS); the third study reported that the ratio of D2‐40 + over factor VIII + vessels is associated with low OS. Most of the other markers had controversial results for prognostication. We found higher expression of MVD/LVD markers were commonly, but not always, associated with shorter survival in TSCC patients. It is therefore not currently possible to recommend implementation of these markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed. Abstract : Higher expression of vessel markers is commonly, but not always, associated with shorter survival in patients with tongue squamous cell carcinoma. It is not currently possible to recommend implementation of any vessel markers as reliable prognosticators in clinical practice. More studies (especially for D2‐40) with larger patient cohorts are needed.