Dupilumab and alopecia: A Janus effect. Issue 5 (24th July 2019)

• Record Type: Journal Article
• Authors: Patruno, Cataldo; Napolitano, Maddalena; Ferrillo, Maria; Fabbrocini, Gabriella
• Is Part Of: Dermatologic therapy. Volume 32:Issue 5(2019)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2019-07-24
• Subjects: adult atopic dermatitis -- alopecia areata -- drug reaction -- dupilumab -- paradox reaction; Skin -- Diseases -- Periodicals; Dermatology -- Periodicals; 616.5
• DOI: 10.1111/dth.13023
• Languages: English
• ISSNs: 1396-0296

Abstract

Abstract: Atopic dermatitis (AD) and alopecia areata (AA) are two common skin diseases that can coexist in the same patient, sharing some pathogenetic mechanisms such as the overexpression of interleukin 4 (IL4) and interleukin 13 (IL13). Recently, cases of AA healing during treatment with anti‐IL4/IL13 monoclonal antibody dupilumab (D) for AD were reported. However, cases of appearance of AA have been described during D treatment too. We report two patients that experienced these two opposite effects of D.