Non-coding RNAs – A primer for the laboratory scientist. Issue 4 (2nd October 2019)

• Record Type: Journal Article
• Authors: Waller, P; Blann, AD
• Is Part Of: British journal of biomedical science. Volume 76:Issue 4(2019)
• Page Start: 157
• Page End: 165
• Publication Date: 2019-10-02
• Subjects: miRNA -- ncRNA -- lncRNA; Medical sciences -- Periodicals; Medical technology -- Periodicals; Biological Science Disciplines; Clinical Laboratory Techniques; Medical Laboratory Science; Anatomie pathologique; Medical sciences; Medical technology; Klinische chemie; Laboratoriumonderzoek; Periodicals; Periodicals; 616.0756; 610.07 M489L
• DOI: 10.1080/09674845.2019.1675847
• Languages: English
• ISSNs: 0967-4845

Abstract

ABSTRACT: Advances in molecular genetics have identified several species of RNA that fail to translate – hence the non-coding RNAs. The two major groups within this class of nucleic acids are microRNAs (miRNA) and long non-coding RNAs (lncRNA). There is growing body of evidence supporting the view that these molecules have regulatory effect on both DNA and RNA. The objective of this brief review is to explain the molecular genetic of these molecules, to summarize their potential as mediators of disease, and to highlight their value as diagnostic markers and as tools in disease management.