Nanoceria as a DNase I mimicking nanozyme. Issue 88 (2nd October 2019)

• Record Type: Journal Article
• Authors: Xu, Fang; Lu, Qinwei; Huang, Po-Jung Jimmy; Liu, Juewen
• Is Part Of: Chemical communications. Volume 55:Issue 88(2019)
• Page Start: 13215
• Page End: 13218
• Publication Date: 2019-10-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc06782e
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Nanoceria mimics DNase I activity by hydrolytically cleaving DNA down to around 5-mer fragments, demonstrating adsorption, reaction and desorption mechanisms typical of heterogeneous catalysts. Abstract : We herein communicate the DNase I like activity of nanoceria (CeO2 nanoparticles). Both CeO2 and DNase I cleave polyadenine (poly-A) DNA down to ∼5-mer fragments as the major products, although further cleavage to even shorter fragments was observed with CeO2 . Mass spectrometry indicates a hydrolytic cleavage mechanism instead of oxidative cleavage.