Assessment of active tuberculosis findings in the eastern area of China: A 3-year sequential screening study. (November 2019)

• Record Type: Journal Article
• Authors: Liu, Kui; Peng, Ying; Zhou, Qinrong; Cheng, Jun; Yu, Hao; Tang, Lihong; Chen, Bin; Wang, Wei; Wang, Fei; He, Tieniu; Zhang, Yu; Zhou, Lin; Chen, Songhua; Chai, Chengliang; Bao, Hongdan; Wang, Xiaomeng; Jiang, Jianmin
• Is Part Of: International journal of infectious diseases. Volume 88(2019)
• Page Start: 34
• Page End: 40
• Publication Date: 2019-11
• Subjects: Tuberculosis -- Active screening -- High prevalence -- Target population; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2019.07.029
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: Our evidence has shown that active case-finding of tuberculosis might be effective in high prevalence area with a low economic level, particularly among the elderly and people with a history of TB. New rapid diagnosis technology should be considered to decrease the TB prevalence in people with a history of TB. ACF screening could identify more active TB cases than PCF by a TB surveillance system in high prevalence area with underdeveloped economics. Abstract: Background: Tuberculosis (TB) is a critical global public threat, and limited epidemiology studies have been performed to explore the efficacy of active TB screening. Methods: Three sites located in eastern China were chosen in 2013, and three rounds of systematic screenings were performed in permanent residents aged older than 15 years. Results: The TB incidence showed a downtrend after several rounds of active screening at the three sites, and a significant change was observed at site A in the overall population. In the target population at sites A and B, both the elderly and people with a history of TB had a remarkable decline through the first or second round of screening. The implementation of active case-finding identified 2.36 [1.47, 3.81] (2013 vs. 2012) and 1.49 [1.1, 2.03] (2013–2015 vs. 2010–2012) more potential cases than the passive case-finding by the surveillance system at site A. Conclusions: Active case-finding of tuberculosis might be effective in high prevalence area with a low economic level, particularly among the elderly and people with a history of TB. Additionally, new rapid diagnosis technology should be considered to decrease the prevalence among people with a history of TB. Ultimately, active screening identified more active TB cases than passive case-finding, particularly in high prevalence area with underdeveloped economics.