Combined toxicity of outdoor air pollution on kidney function among adult women in Mianyang City, southwest China. (January 2020)

• Record Type: Journal Article
• Authors: Wang, Huan-Huan; Zhang, Shao-Cheng; Wang, Jing; Chen, Xi; Yin, Heng; Huang, Dong-Yang
• Is Part Of: Chemosphere. Volume 238(2020)
• Publication Date: 2020-01
• Subjects: Combined toxicity -- Outdoor air pollution -- Cystatin C -- Estimated glomerular filtration rate -- Adult women -- China; CKD chronic kidney disease -- eGFR estimated glomerular filtration rate -- ADD average daily dose -- AQCI air quality complex index -- NAAQS-China the national ambient air quality standard of China -- HDL high-density lipoprotein -- LDL low-density lipoprotein -- AST aspartate amino transferase -- ALT alanine amino transferase -- GGT gamma-glutamyl transpeptidase; Pollution -- Periodicals; Pollution -- Physiological effect -- Periodicals; Environmental sciences -- Periodicals; Atmospheric chemistry -- Periodicals; 551.511
• DOI: 10.1016/j.chemosphere.2019.124603
• Languages: English
• ISSNs: 0045-6535

Abstract

Abstract: Environmental pollution is a risk factor for kidney dysfunction. However, the combined toxicity of air pollutants on kidney function is scarce. We estimated the relationship between combined toxicity of air pollutants and kidney function among adult women (n = 7071, 18–65 years old) in Mianyang City, Southwest China. We measured serum concentrations of uric acid, urea, creatinine, and cystatin C, and we calculated the individual estimated glomerular filtration rate (eGFR) using a cystatin C-based equation developed specifically for Chinese patients with CKD equation. Air pollution data were collected to calculate the individual average daily dose (ADD) of pollutants based on the air quality complex index (AQCI). Mean AQCI was higher in winter and lower in summer, and followed the monthly and seasonal trends of air pollutants. Concomitantly, individual ADD was also higher in winter and lower in summer, and the seasonal differences were reflected in the levels of kidney biomarkers (including uric acid, urea, creatinine, cystatin C, and eGFR). With an interquartile range (IQR: 1.04–1.50 m 3 /day/kg) increases of ADD, the serum concentrations of uric acid, urea, creatinine, and cystatin C increase [B (95%CI): 1.774 (0.318, 3.231) umol/L, 0.218 (0.1888, 0.247) mmol/L, 1.501 (1.016, 1.986) umol/L, and 0.006 (0.003, 0.009) mg/L, respectively], whereas eGFR decreases [B (95%CI): -0.776 (−1.106, −0.446) mL/min/1.73 m 2 ]. Totally, the relationship between combined toxicity of air pollutants and kidney function in Chinese adult women suggests that the toxicity of combined air pollutants inversely affects kidney function, which might accelerate the risk of CKD. Highlights: First study on relationship between combined toxicity of air pollution and kidney function. Individual eGFR was estimated by the Cystatin C-Based Chinese Patients with CKD Equation. We calculated individual average daily dose (ADD) of air quality complex index (AQCI). ADD, with an IQR increased, was negatively associated with eGFR. Combined toxicity of air pollution inversely affects individual kidney function.