Stimuli-responsive hydrogels for manipulation of cell microenvironment: From chemistry to biofabrication technology. (November 2019)

• Record Type: Journal Article
• Authors: Mohamed, Mohamed Alaa; Fallahi, Afsoon; El-Sokkary, Ahmed M.A.; Salehi, Sahar; Akl, Magda A.; Jafari, Amin; Tamayol, Ali; Fenniri, Hicham; Khademhosseini, Ali; Andreadis, Stelios T.; Cheng, Chong
• Is Part Of: Progress in polymer science. Volume 98(2019)
• Publication Date: 2019-11
• Subjects: μCP microcontact printing -- τ1/2 stress relaxation time constant -- 2D two-dimensional -- 3D three-dimensional -- 4D four-dimensional -- AA-MA methacrylated alginate -- BA benzophenone acrylate -- BMP bone morphogenetic protein -- CDs cyclodextrins -- CNTF ciliary neurotrophic factor -- DMAEMA 2-(dimethylamino)ethyl methacrylate -- DOPA 3, 4-dihydroxyphenylalanine -- ECM extracellular matrix -- EDTA ethylenediaminetetraacetic acid -- EGF epidermal growth factor -- ELP elastin-like polypeptides -- ESMNs embryonic stem cell-derived motor neurons -- FGF2 fibroblast growth factor basic -- FGFs fibroblast growth factors -- Fmoc fluoren-9-ylmethoxy)carbonyl -- FN fibronectin -- FXIIIa transglutaminase factor XIII enzyme -- GAGs glycosaminoglycans -- GelMA methacrylated gelatin -- GNR gold nanorod -- HA hyaluronic acid -- HA-MA methacrylated hyaluronic acid -- HDFBs human dermal fibroblasts -- HEMA 2-hydroxyethyl methacrylate -- hMSCs human mesenchymal stem cells -- HRP horseradish peroxidase -- HSFs human skin fibroblasts -- HUVSMCs human umbilical vein smooth muscle cells -- K-ELP lysine-containing elastin-like polypeptides -- LCST lower critical solution temperature -- mESCs mouse embryonic stem cells -- MMP matrix metalloproteinase -- NFC nanofibrillated cellulose -- NGF neural growth factor -- NIPAM N-isopropylacrylamide -- NPPOC 2-(2-nitrophenyl) propyloxycarbonyl -- oNB o-nitrobenzyl -- PAA poly(acrylic acid) -- PMMA poly(methyl methacrylate) -- PNIPAM poly(N-isopropylacrylamide) -- poly(HPMA-co-HEMA) poly((N-(2-hydroxypropyl)-methacrylamide)-co-2-hydroxyethyl methacrylate) -- poly(MMA-co-BA) poly(methyl methacrylate-co-benzophenone acrylate) -- poly(NIPAM-co-AA) poly(N-isopropylacrylamide-co-acrylic acid) -- poly(NIPAM-co-AA-co-BA) poly(N-isopropylacrylamide-co-acrylic acid-co-benzophenone acrylate) -- poly(PEGDMA-co-DMAEMA) poly(PEG dimethacrylate-co-2-(dimethylamino)ethyl methacrylate) -- poly(SMA-co-BA) poly(stearyl methacrylate-co-benzophenone acrylate) -- PSCs pancreatic stellate cells -- PVA poly(vinyl alcohol) -- RGD Arg-Gly-Asp -- RGDS Arg-Gly-Asp-Ser -- RGES Arg-Gly-Glu-Ser -- SAM self-assembled monolayer -- SMPs shape memory polymers -- TE tissue engineering -- TGF-β transforming growth factor-β -- TGFβ1 transforming growth factor β1 -- UCST upper critical solution temperature -- UPy 4-ureido-2-pyrimidone -- VEGF vascular endothelial growth factor -- VSMCs vascular smooth muscle cells; Stimuli-responsive hydrogels -- Cellular microenvironment -- Cell-biomaterial interaction -- Spatiotemporal modulation -- Dynamic biomaterials -- Biofabrication technology; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2019.101147
• Languages: English
• ISSNs: 0079-6700

Abstract

Graphical abstract: Abstract: Native tissues orchestrate their functions by complex interdependent cascades of biochemical and biophysical cues that vary spatially and temporally during cellular processes. Scaffolds with well-tuned structural, mechanical, and biochemical properties have been developed to guide cell behavior and provide insight on cell-matrix interaction. However, static scaffolds very often fail to mimic the dynamicity of native extracellular matrices. Stimuli-responsive scaffolds have emerged as powerful platforms that capture vital features of native tissues owing to their ability to change chemical and physical properties in response to cytocompatible stimuli, thus enabling on-demand manipulation of cell microenvironment. The vast expansion in biorthogonal chemistries and stimuli-responsive functionalities has fuelled further the development of new smart scaffolds that can permit multiple irreversible or reversible spatiotemporal modulation of cell-directing cues, thereby prompting in-depth studies to interpret the decisive elements that regulate cell behavior. Integration of stimuli-responsive hydrogels with current biofabrication technologies has allowed the development of dynamic scaffolds with organizational features and hierarchical architectures similar to native tissues. This review highlights the progress achieved using stimuli-responsive hydrogels in fundamental cell biology studies, with particular emphasis on the interplay between chemistry, biomaterials design, and biofabrication technologies for manipulation of cell microenvironment.