Progress of supercritical fluid technology in polymerization and its applications in biomedical engineering. (November 2019)

• Record Type: Journal Article
• Authors: Tsai, Wen-Chyan; Wang, Yadong
• Is Part Of: Progress in polymer science. Volume 98(2019)
• Publication Date: 2019-11
• Subjects: AA acrylic acid -- AB ammonium bicarbonate -- AIBN 2, 20-Azobisisobutyronitrile -- ASES aerosol solvent extraction system -- AUL absorption under load -- C6 coumarin-6 -- CALB Candida antarctica lipase B -- coQ10 coenzyme Q10 -- CRL Candida rugosa lipase -- DDMAT 2(Dodecylthiocarbonothioylthio)-2-methylpropionic acid -- DELOS depressurization of an expanded liquid organic solution -- GF growth factors -- DTBP Di-tert-butyl Peroxide -- EGDMA ethylene glycol dimethacrylate -- hASC human adipose-derived stem cell -- HEMA 2-hydroxyethyl methacrylate -- HFP hexafluoropropylene -- HLB hydrophilic-lipophilic balance -- MCF mesocellular silica foam -- MMA methyl methacrylate -- MPEG methoxy polyethylene glycol -- MSC mesenchymal stem cells -- MT 17α-methyltestosterone -- NaOH sodium hydroxide -- NIPA N-isopropyl acrylamide -- NVP N-vinyl-2-pyrrolidone -- Pc critical pressure -- PAA poly(acrylic acid) -- PBP perfluorobutyryl peroxide -- PCA precipitation with compressed anti-solvent -- PCL polycaprolactone -- PCL–HA polycaprolactone–hydroxyapatite -- PDI (Đ) polydispersity index -- PDLLA poly(D, L-lactic acid) -- PEG polyethylene glycol -- PET polyethylene terephthalate -- PGSS particles from gas saturated solutions -- PHB poly(β-hydroxybutyrate) -- PL platelet lysate -- PLA polylactic acid -- PLDO poly(L-lactide-co-p-dioxanone) -- PLLA poly(L-lactide) -- PMDOP poly(2-methylene-1, 3-dioxepane) -- PMMA polymethyl methacrylate -- PNIPAAm poly(N-isop ropylacrylamide) -- Pro3-TL proline-replaced temporin L analogue -- p-SNP polymer-grafted silica nanoparticle -- PVAc poly(vinyl acetate) -- PVDF polyvinylidene fluoride -- RAFT peversible addition-fragmentation chain transfer -- RESS rapid expansion of a supercritical solution -- ROP ring opening polymerization -- SAS supercritical antisolvent -- SCF supercritical fluid -- SC−CO2 supercritical carbon dioxide -- SEE supercritical emulsion extraction -- SEM scanning electron microscopy -- Sn(Oct)2 stannous 2-ethyl hexanoate -- Tc critical temperature -- Tg glass transition temperature -- Tm melting temperature -- TBTGA S-thiobenzoyl thioglycolic acid -- VF2 vinylidene fluoride; Supercritical fluid -- Lipase -- Biodegradable polyester -- Biomedical engineering -- Microcapsule -- Microcellular scaffold; Polymers -- Periodicals; Polymerization -- Periodicals; Polymers -- Industrial applications -- Periodicals; Polymères -- Périodiques; Polymérisation -- Périodiques; 547.7
• DOI: 10.1016/j.progpolymsci.2019.101161
• Languages: English
• ISSNs: 0079-6700

Abstract

Graphical abstract: Abstract: Supercritical fluid technology has emerged as a cost-effective and low-hazard alternative to solvent-based methodologies in polymer synthesis, pharmaceutical science, and related biomedical applications. In this review, we first briefly describe the distinctive features of a supercritical fluid, biodegradable polyesters, and lipases. We will then cover the latest progress of supercritical fluid technology in polymerization. Lipase-catalyzed polymerization in supercritical carbon dioxide (SC−CO2 ) will be the focus of the synthesis section. The last section presents the biomedical applications employing SC−CO2 polymerization, including microcapsule formation for drug delivery, microcellular scaffold fabrication, and SC−CO2 -assisted processes for polymer-based treatments, such as surface functionalization, aerogel formation, and fine particle formation. Each topic is illustrated with the most successful examples. Understanding the current progress in SC−CO2 polymerization is an essential step to facilitate the exploration with this green technology in new research frontiers.