Organocatalytic Green Approach Towards the Fabrication of Fused Benzo N, N‐containing Heterocycles Facilitated by Ultrasonic Irradiation. (22nd August 2019)

• Record Type: Journal Article
• Authors: Nongrum, Ridaphun; Kharmawlong, George Kupar; Rani, Jims World Star; Rahman, Noimur; Dutta, Arup; Nongkhlaw, Rishanlang
• Is Part Of: Journal of heterocyclic chemistry. Volume 56:Number 10(2019)
• Page Start: 2873.
• Page End: 2883
• Publication Date: 2019-08-22
• Subjects: Heterocyclic compounds -- Periodicals; 547.59
• DOI: 10.1002/jhet.3680
• Languages: English
• ISSNs: 0022-152X

Abstract

Abstract : The development of a metal‐free protocol for transformations in organic synthesis offers a significant potential environmental benefit. This article reports the exploration of meglumine, a nontoxic and biodegradable amino sugar, as an organocatalyst for the synthesis of biologically active 1 H ‐dibenzo[ b, e ][1, 4]diazepin‐1‐ones, highly regioselective benzimidazole derivatives and derivatives of quinoxalines. Operational simplicity, mild reaction conditions, shorter reaction times, and use of green solvents are the highlights of this protocol. The advantage of ultrasonic irradiation has been significantly explored for the synthesis of the aforesaid compounds. Furthermore, the multifaceted use of o ‐phenylenediamine has also been accentuated in the study. Abstract :