CD13 regulation of membrane recycling: implications for cancer dissemination. (2nd November 2019)

• Record Type: Journal Article
• Authors: Ghosh, Mallika; Shapiro, Linda H.
• Is Part Of: Molecular & cellular oncology. Volume 6:Number 6(2019)
• Publication Date: 2019-11-02
• Subjects: CD13 -- anpep -- membrane recycling -- endocytosis; Tumors -- Periodicals; Neoplasms; Periodicals; 616.99
• DOI: 10.1080/23723556.2019.1648024
• Languages: English
• ISSNs: 2372-3556

Abstract

ABSTRACT: Membrane recycling is critical to numerous cell functions and its dysregulation contributes to cancer and metastasis. We established that activation of the transmembrane molecule aminopeptidase N (ANPEP, also known as CD13) tethers the IQ motif containing, guanosine triphosphate hydrolase activating protein 1 (IQGAP1) scaffolding protein at the plasma membrane, thus stimulating the recycling regulator ADP-ribosylation factor 6 (ARF6) to ensure proper recycling of β1-integrin and other membrane components impacting cell attachment.