Proline-promoted dehydroxylation of α-ketols. Issue 40 (28th August 2019)

• Record Type: Journal Article
• Authors: Mostinski, Yelena; Lankri, David; Konovalov, Yana; Nataf, Riva; Tsvelikhovsky, Dmitry
• Is Part Of: Chemical science. Volume 10:Issue 40(2019)
• Page Start: 9345
• Page End: 9350
• Publication Date: 2019-08-28
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9sc02543j
• Languages: English
• ISSNs: 2041-6520

Abstract

Abstract : A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. Abstract : A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups.