A141 PREVALENCE OF CELIAC DISEASE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS. (15th March 2019)

• Record Type: Journal Article
• Authors: Callichurn, K; Cvetkovic, L; Therrien, A; Vincent, C; Bouin, M
• Is Part Of: Journal of the Canadian Association of Gastroenterology. Volume 2(2019)Supplement 2
• Page Start: 281
• Page End: 281
• Publication Date: 2019-03-15
• Subjects: Gastroenterology -- Periodicals; 616.33005
• DOI: 10.1093/jcag/gwz006.140
• Languages: English
• ISSNs: 2515-2084

Abstract

Abstract: Background: Primary biliary cholangitis (PBC) is an autoimmune chronic liver disease, affecting mostly women. PBC frequently coexists with other autoimmune diseases, including celiac disease (CD). Although the prevalence of CD is high among cohorts with PBC, few studies have directly compared this prevalence to those among individuals with other liver diseases (OLD). Aims: To compare the prevalence of CD between a cohort with PBC and a cohort with OLD. Methods: Retrospective study from 2013 to 2016. All consecutive patients with an anti-transglutaminase assay requested by a hepatologist and a diagnosis of chronic liver disease were included. The diagnosis of CD had to be confirmed histologically by a small intestinal biopsy. The groups were compared by chi-square tests. Results: We included 399 patients (53.1 years SD 14.0, 54.1% women), including 51 patients with PBC and 348 patients with OLD. The PBC and OLD groups were different for the gender (90.2% vs. 48.9% women, p <0.0001). The prevalence of CD was higher in the group with PBC compared to the group with OLD (11.8 vs 2.9%, p <0.003). In the OLD group, the prevalence of CD was comparable regardless of the etiologic subgroup (NASH 2.7% vs. ROH 4.3%, vs viral 1.5% vs other autoimmune liver diseases 3.3%). The most common reasons for CD screening among PBC patients were the presence of PBC (33.3%) and the etiologic assessment of liver disease (31.4%), whereas for patients with OLD, it was etiologic assessment of liver disease (39.1%) or cytolysis (25.6%). The presence of gastrointestinal symptoms was comparable between PBC and OLD groups (31.4 vs 29.6%, NS). Conclusions: There is a higher prevalence of CD in the PBC group compared to the other liver diseases group. Funding Agencies: None