0482 Distribution of Fat in Pre- and Post-Menopausal Females with Sleep Related Breathing Disorder. (12th April 2019)

• Record Type: Journal Article
• Authors: Pusalavidyasagar, Snigdha; Abbasi, Adnan
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A193
• Page End: A193
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.480
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: Obstructive sleep apnea is the by far the most common sleep related breathing disorder (SRBD). It is associated with obesity and increased visceral adipose tissue. The aim of this investigation is to study fat distribution in pre- and post-menopausal females with SRBD. Methods: This cross-sectional population-based study included national representative sample of NHANES 2005-2006. Adult females of ≥ 18 years of age were included (n=2, 374). Demographic, questionnaire and examination data, and dual-energy X-ray absorptiometry measured fat mass were obtained. STOP questionnaire, with a score of 2 or more, has been validated to predict SRBD. Subject's response to questions on snoring, snorts/witnessed apneas, daytime sleepiness and hypertension (high blood pressure (BP) on ≥2 times, taking anti-hypertensive medications, or BP ≥ 140/90 mmHg) were used to stratify subjects with SRBD. An age cut-off of 55 years was used as a surrogate for menopausal status. Results: A total of 470 subjects were identified with SRBD, 155 subjects in age group ≥ 55 years and 315 subjects in age group < 55 years. Body mass index (BMI), waist circumference, total fat percentage, trunk fat percentage, and waist to hip fat ratio were significantly (p <0.001) higher in subjects with SRBD compared to subjects without SRBD. In subjects with SRBD, BMI, waist circumference, total fat percentage, trunk fat percentage were similar, in ≥ 55years and <55 years, at 31.6 ± 0.95 vs. 32.6 ± 0.59 kg/m 2, 103 ± 1.89 vs. 102 ± 1.2 cm, 43.1 ± 0.64 vs. 41.9 ± 0.54%, 42.4 ± 0.73 vs. 41.1 ± 0.61% (all p-values NS) respectively. Waist to hip fat ratio was significantly higher in females with SRBD compared to no SRBD; In <55 years group at 0.97 ± 0.02% vs. 0.86 ± 0.01% (p <0.001), and ≥ 55 years group at 0.96 ± 0.01% vs. 0.89 ± 0.01% (p <0.001). Conclusion: Adult females with SRBD have significantly higher body fat compared to females without SRBD. Similar fat distribution was observed in pre- and post-menopausal females with SRBD. Support (If Any): CDC for NHANES data.