0596 Polysomnographic Findings And Disordered Behavior Related To Rem Sleep Of Patients With Narcolepsy. (12th April 2019)

• Record Type: Journal Article
• Authors: Yagi, Tomoko; Chiba, Shintaro; Itoh, Hiroshi
• Is Part Of: Sleep. Volume 42(2019)Supplement 1
• Page Start: A237
• Page End: A238
• Publication Date: 2019-04-12
• Subjects: Sleep -- Physiological aspects -- Periodicals; Sleep disorders -- Periodicals; Sommeil -- Aspect physiologique -- Périodiques; Sommeil, Troubles du -- Périodiques; Sleep disorders; Sleep -- Physiological aspects; Sleep -- physiological aspects; Sleep Wake Disorders; Psychophysiology; Electronic journals; Periodicals; 616.8498
• DOI: 10.1093/sleep/zsz067.594
• Languages: English
• ISSNs: 0161-8105

Abstract

Abstract: Introduction: REM sleep behavior disorder (RBD), REM without atonia (RWA) and periodic limb movements in sleep (PLMS) are known as symptoms of Narcolepsy as it is listed in the International Classification of Sleep Disorders, third edition (ICSD3). The purpose of this study is to summarize polysomnographic findings and abnormal behavior related to REM sleep of patients with Narcolepsy diagnosed in our sleep clinic. Methods: We conducted polysomnography (PSG) and multiple sleep latency test (MSLT) with 588 patients from the period of 2011 to 2016, 139 patients (80 male, 59 female patients, an average of 24.4yrs.) are diagnosed with Narcolepsy. Although cerebrospinal fluid orexin concentration measurement is not performed, narcolepsy with cataplexy attack is classified as type 1 (22 male and 26 female patients), narcolepsy without cataplexy attack is classified as type 2 (58 male, 33 female patients). We compared it about a difference of PSG and MSLT parameters and incidence of disordered behavior between Narcolepsy Type1 group and Type2 group. MannWhitney U test was used for the comparison between two groups. Results: A significant difference was found between Narcolepsy Type1 and Type2 of REM sleep latency, %stageR, %RWA, and PLMSI in the PSG findings. In the MSLT findings, sleep latency was short and the number of SOREMP was increased in Type1 group. Rude behavior was observed at a higher rate in Type 1 patients than in Type 2 patients. Conclusion: Our study showed that it was evident Narcolepsy Type1 patients having more REM related polysomnographic findings and rude behavior than Type2 patients. Support (If Any): none