Preparation and characterization of catechol-functionalized chitosan thermosensitive hydrogels. (September 2019)

• Record Type: Journal Article
• Authors: Zhang, D Y; Hu, Z; Lu, S T; Li, S D; Yang, Z M; Li, P W
• Is Part Of: IOP conference series. Volume 629(2019)
• Publication Date: 2019-09
• Subjects: Materials science -- Periodicals; 620.1105
• DOI: 10.1088/1757-899X/629/1/012038
• Languages: English
• ISSNs: 1757-8981

Abstract

Abstract: Catechol functionalization of chitosan was modified by EDC coupling reaction and then catechol-functionalized chitosan thermosensitive hydrogels were prepared by catechol-functionalization of chitosan with β-glycerophosphate disodium as a thermosensitizer. The hydrogels were then characterized by FTIR, 1 H-NMR, SEM and rheology analysis. The results demonstrated that the thermosensitive hydrogels were prepared at 37°C within several minutes by mixing 2% catechol-functionalized chitosan with 30% β-glycerophosphate disodium at a ratio of 8:2, and these thermosensitive hydrogels with porous network structure were expected to be developed as biomedical materials with wide applications.