Polymyxin derivatives as broad-spectrum antibiotic agents. Issue 87 (15th October 2019)

• Record Type: Journal Article
• Authors: Su, Ma; Wang, Minghui; Hong, Yuzhu; Nimmagadda, Alekhya; Shen, Ning; Shi, Yan; Gao, Ruixuan; Zhang, En; Cao, Chuanhai; Cai, Jianfeng
• Is Part Of: Chemical communications. Volume 55:Issue 87(2019)
• Page Start: 13104
• Page End: 13107
• Publication Date: 2019-10-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc06908a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : A few polymyxin derivatives with broad-spectrum antimicrobial activity were developed. Lead compound P1 disrupted bacterial membranes rapidly without developing resistance. Abstract : We designed a few polymyxin derivatives which exhibit broad-spectrum antimicrobial activity. Lead compound P1 could disrupt bacterial membranes rapidly without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in an MRSA-infected thigh burden mouse model.