Pd-Catalyzed regio- and enantioselective allylic substitution with 2-pyridones. Issue 87 (16th October 2019)

• Record Type: Journal Article
• Authors: Khan, Sardaraz; Shah, Babar Hussain; Khan, Ijaz; Li, Meiqi; Zhang, Yong Jian
• Is Part Of: Chemical communications. Volume 55:Issue 87(2019)
• Page Start: 13168
• Page End: 13171
• Publication Date: 2019-10-16
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc07482a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : An efficient method for the asymmetric synthesis of N -substituted 2-pyridones via a Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. Abstract : An efficient method for the asymmetric synthesis of N -substituted 2-pyridones via Pd-catalyzed regio- and enantioselective allylic substitution of hydroxyl-containing allylic carbonates with 2-pyridones has been developed. By using a palladium complex in situ generated from Pd2 (dba)3 ·CHCl3 and phosphoramidite L2 as a ligand, the process allowed rapid access to N -substituted 2-pyridones with complete chemo- and regioselectivities and good to high enantioselectivities.