Integrating chemical and mechanical signals in neural crest cell migration. (August 2019)

• Record Type: Journal Article
• Authors: Shellard, Adam; Mayor, Roberto
• Is Part Of: Current opinion in genetics & development. Volume 57(2019)
• Page Start: 16
• Page End: 24
• Publication Date: 2019-08
• Subjects: Genetics -- Periodicals; Developmental biology -- Periodicals; Developmental genetics -- Periodicals; 576.5
• DOI: 10.1016/j.gde.2019.06.004
• Languages: English
• ISSNs: 0959-437X

Abstract

Abstract : Neural crest cells are a multipotent embryonic stem cell population that migrate large distances to contribute a variety of tissues. The cranial neural crest, which contribute to tissues of the face and skull, undergo collective migration whose movement has been likened to cancer metastasis. Over the last few years, a variety of mechanisms for the guidance of collective cranial neural crest cell migration have been described: mostly chemical, but more recently mechanical. Here we review these different mechanisms and attempt to integrate them to provide a unified model of collective cranial neural crest cell migration.