A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform. Issue 85 (10th October 2019)
- Record Type:
- Journal Article
- Title:
- A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform. Issue 85 (10th October 2019)
- Main Title:
- A chromenone analog as an ATP-competitive, DNA non-intercalative topoisomerase II catalytic inhibitor with preferences toward the alpha isoform
- Authors:
- Park, Seojeong
Hwang, Soo-Yeon
Shin, Jaeho
Jo, Hyunji
Na, Younghwa
Kwon, Youngjoo - Abstract:
- Abstract : Compound 52 exhibited highly topo IIα-selective properties as an ATP competitive catalytic inhibitor with less toxicity, unlike topo II poisons. Abstract : 5-Hydroxy-2-phenyl-7-(thiiran-2-ylmethoxy)-4 H -chromen-4-one (compound 52 ) was found as a DNA non-intercalative topo II specific catalytic inhibitor by targeting its ATP-binding domain. Showing changes in interaction with Mg 2+, it exhibited highly selective properties against the α-isoform with less toxicity, unlike other topo II poisons, such as etoposide.
- Is Part Of:
- Chemical communications. Volume 55:Issue 85(2019)
- Journal:
- Chemical communications
- Issue:
- Volume 55:Issue 85(2019)
- Issue Display:
- Volume 55, Issue 85 (2019)
- Year:
- 2019
- Volume:
- 55
- Issue:
- 85
- Issue Sort Value:
- 2019-0055-0085-0000
- Page Start:
- 12857
- Page End:
- 12860
- Publication Date:
- 2019-10-10
- Subjects:
- Chemistry -- Periodicals
540 - Journal URLs:
- http://pubs.rsc.org/en/journals/journalissues/cc ↗
http://www.rsc.org/ ↗ - DOI:
- 10.1039/c9cc05524j ↗
- Languages:
- English
- ISSNs:
- 1359-7345
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 3139.350000
British Library DSC - BLDSS-3PM
British Library STI - ELD Digital store - Ingest File:
- 12031.xml