Heterocyclic iodoniums as versatile synthons to approach diversified polycyclic heteroarenes. Issue 57 (16th October 2019)

• Record Type: Journal Article
• Authors: Zhu, Daqian; Wu, Zhouming; Liang, Liyun; Sun, Yameng; Luo, Bingling; Huang, Peng; Wen, Shijun
• Is Part Of: RSC advances. Volume 9:Issue 57(2019)
• Page Start: 33170
• Page End: 33179
• Publication Date: 2019-10-16
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra07288h
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The transformation of heterocyclic iodoniums led to the construction of heterocycles with a high structural diversity. Abstract : Polycyclic heteroarenes are important scaffolds in the construction of pharmaceuticals. We have previously developed a series of novel heterocyclic iodoniums. In our current work, these unique iodoniums were employed to construct various complex polycyclic heteroarenes with structural diversity via tandem dual arylations. As a result, indole, thiophene and triphenylene motifs were fused into these heterocycles with high molecular quality, which might provide promising fragments in drug discovery. Moreover, these heterocycles could be diversified at a late stage.