Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition. Issue 84 (3rd October 2019)

• Record Type: Journal Article
• Authors: Liang, Jun; Gong, Qingyue; Li, Ying; Zheng, Yong; Zheng, Ji-Shen; Tian, Changlin; Li, Jia-Bin
• Is Part Of: Chemical communications. Volume 55:Issue 84(2019)
• Page Start: 12639
• Page End: 12642
• Publication Date: 2019-10-03
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc05526f
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Four diubiquitinated H2A analogues were newly synthesized and used to reveal the plasticity of ubiquitin chains in 53BP1 recognition. Abstract : Polyubiquitination with diverse linkages on histones provides another layer of accuracy and complexity for epigenetic regulation, which is rarely studied. Herein, K27 or K48-diubiquitin modified H2A analogues were chemically synthesized using thiirane linkers. These permitted in vitro binding studies suggested the plasticity of ubiquitin chains in 53BP1 recognition.