Fe3O4–Pd Janus nanoparticles with amplified dual-mode hyperthermia and enhanced ROS generation for breast cancer treatment. Issue 6 (13th August 2019)

• Record Type: Journal Article
• Authors: Ma, Xiaowei; Wang, Yanyun; Liu, Xiao-Li; Ma, Huijun; Li, Galong; Li, Yao; Gao, Fei; Peng, Mingli; Fan, Hai Ming; Liang, Xing-Jie
• Is Part Of: Nanoscale horizons. Volume 4:Issue 6(2019)
• Page Start: 1450
• Page End: 1459
• Publication Date: 2019-08-13
• Subjects: Nanoscience -- Periodicals; Nanotechnology -- Periodicals; 620.505
• DOI: 10.1039/c9nh00233b
• Languages: English
• ISSNs: 2055-6756

Abstract

Abstract : Biocompatible Fe3 O4 -Pd Janus nanoparticles were designed to achieve significantly high magnetic-photo heating efficiency accompanied by enhanced ROS generation for efficient cancer therapy. Abstract : Developing multifunctional theranostic nanoplatforms with high tumor therapeutic efficacy is the focus area of nanomedicine. In this study, we have designed Fe3 O4 –Pd Janus nanoparticles (JNPs) with dual-mode magnetic resonance imaging/photoacoustic (MRI/PA) imaging properties for magnetic-photo hyperthermia and chemodynamic therapy simultaneously. Due to the magnetic-photothermal properties of Fe3 O4 nanoparticles and plasmonic photothermia effect of Pd nanosheets, the combined Fe3 O4 –Pd JNPs can achieve synergistic heating effects of 1 + 1 > 2. It is demonstrated that Fe3 O4 –Pd JNPs reached a higher temperature enhancement under alternating magnetic field (AMF) plus laser irradiation than the corresponding individual modality (only AMF or laser irradiation alone for Fe3 O4 –Pd JNPs) or the sum of two individual modalities. Besides amplified magnetic-photo heating, Fe3 O4 –Pd JNPs also enhanced ROS generation due to the interface synergistic effect in producing hydroxyl radicals (˙OH), which is realized by Fe3 O4 nanoparticle-based Fenton reaction and Pd nanosheet-based catalytic properties in the presence of H2 O2 in an acidic environment. Remarkably, the ROS level could be further elevated under external AMF plus laser irradiation. The in vivo anti-tumor effect of Fe3 O4 –Pd JNPs was evaluated on a 4T1 orthotopic mouse breast cancer model. The results showed that Fe3 O4 –Pd JNPs enable complete tumor inhibition without appreciable adverse effects under AMF plus laser irradiation, guided by MRI/PA dual-mode imaging with a high spatial resolution and accuracy. This study provides an alternative way for cancer therapy by on-demand design of high-performance theranostic nanoplatforms according to the characteristics of the tumor microenvironment and the intriguing physiochemical properties of inorganic nanomaterials.