Cytotoxic effect, generation of reactive oxygen/nitrogen species and electrochemical properties of Cu(ii) complexes in comparison to half-sandwich complexes of Ru(ii) with aminochromone derivatives. Issue 55 (8th October 2019)

• Record Type: Journal Article
• Authors: Mucha, Paulina; Hikisz, Pawel; Gwoździński, Krzysztof; Krajewska, Urszula; Leniart, Andrzej; Budzisz, Elzbieta
• Is Part Of: RSC advances. Volume 9:Issue 55(2019)
• Page Start: 31943
• Page End: 31952
• Publication Date: 2019-10-08
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra05971g
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : New Cu(ii )/Ru(ii ) complexes with 6-aminoflavone/chromone derivatives as ligands were synthesized and characterized. Their cytotoxicity, pro-oxidative and redox properties were investigated. Abstract : This paper describes the synthesis of new 6-aminoflavone (6AFl (3 )) and 6-aminochromone (6AC (4 )) complexes with Cu(ii ) and Ru(ii ) ions ([Cu(6AC)2 Cl2 ] (3a ), [Cu(6AFl)2 Cl2 ] (4a ), [Ru( p -cymene)(6AC)Cl2 ] (4b )) and comparison of their properties with the previously described 7-aminoflavone (7AFl (1 )) and 7-amino-2-methylchromone (7A2MC (2 )) analogues. The cytotoxic effect of all these complexes against two human leukaemia cell lines (HL-60 and NALM-6), melanoma WM-115 cells and COLO205 cells, is determined. The cytotoxicity of copper(ii ) complexes, especially [Cu(6AFl)2 Cl2 ] (3a ) was higher than ruthenium(ii ) complexes with the same ligands. Their cytotoxic potency was also stronger in comparison to the referential agents like cisplatin. The pro-oxidative properties were determined for the most active complexes and their ability to generate ROS (reactive oxygen species)/RNS (reactive nitrogen species) in cancer cells was confirmed. The type of ligand and the chemical structure of the tested complexes had an influence on the level of ROS/RNS generated in cancer cells. The redox properties of the copper complex compounds were evaluated by cyclic voltammetry, and compared with the data for Ru(ii ) complexes. The reduction and oxidation processes of Ru(iii )/Ru(ii ) and Cu(ii )/Cu(i ) were described as quasi-reversible.