The remarkable UV light invulnerability of thymine GNA dinucleotides. Issue 83 (2nd October 2019)

• Record Type: Journal Article
• Authors: Coantic-Castex, Stéphanie; Martinez, Agathe; Harakat, Dominique; Guillaume, Dominique; Clivio, Pascale
• Is Part Of: Chemical communications. Volume 55:Issue 83(2019)
• Page Start: 12571
• Page End: 12574
• Publication Date: 2019-10-02
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc04355a
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : The thymine moieties of GNA dinucleotides exhibit resistance to UV light due to the absence of a stacked conformation suitable for photochemical reaction. Abstract : We herein demonstrate the UV resistance of glycol nucleic acid (GNA) dinucleotides. This resistance sustains the hypothesis of GNA as a nucleic acid prebiotic ancestor on early Earth, a time of intense solar UV light. Such photorobustness, due to the absence of intrastrand base stacking, could offer an opportunity for nanodevice development requiring challenging UV conditions.