Facile access to evodiakine enabled by aerobic copper-catalyzed oxidative rearrangement. Issue 39 (1st October 2019)

• Record Type: Journal Article
• Authors: Su, Yiting; Huang, Gaofeng; Ye, Fu; Qiao, Panpan; Ye, Jinxiang; Gao, Yu; Chen, Haijun
• Is Part Of: Organic & biomolecular chemistry. Volume 17:Issue 39(2019)
• Page Start: 8811
• Page End: 8815
• Publication Date: 2019-10-01
• Subjects: Chemistry, Organic -- Periodicals; Bioorganic chemistry -- Periodicals; Chemistry, Physical organic -- Periodicals; 547
• DOI: 10.1039/c9ob01832h
• Languages: English
• ISSNs: 1477-0520

Abstract

Abstract : Oxidative rearrangement for the first rapid construction of evodiakine was developed. Abstract : Oxidation as a fundamentally important method for the synthesis of complex structures is difficult to achieve in a selective manner. Evodiakine, a complex natural product possessing an unprecedented ring system (6/5/5/7/6), has a high oxidation state without a practical solution. Herein, we report the first synthesis of evodiakine via aerobic copper-catalyzed late-stage functionalization of evodiamine.