Metabolomic Markers of the Relationship Between Sugar-sweetened Beverage Intake and Metabolic Risk in Mexican Adolescents (P08-132-19). (24th October 2019)

• Record Type: Journal Article
• Authors: Perng, Wei; Tang, Lu; Perng, Wei Perng3 Wei; Perng, Wei; Cantoral, Alejandra; Peterson, Karen
• Is Part Of: Current developments in nutrition. Volume 3(2019)Supplement 1
• Publication Date: 2019-10-24
• Subjects: Nutrition -- Periodicals; Nutritional Physiological Phenomena; Nutrition; Periodicals; Periodicals; Fulltext; Internet Resources; Periodicals; 612.3
• DOI: 10.1093/cdn/nzz044.P08-132-19
• Languages: English
• ISSNs: 2475-2991

Abstract

Abstract: Objectives: To identify metabolites that mark the relationship of sugar-sweetened beverage (SSB) intake with adiposity and metabolic risk among boys ( n = 114) and girls ( n = 128) 8–14 years of age. Methods: First, we used linear regression to examine associations of quartiles of SSB intake with adiposity, glycemia, lipid profile, and blood pressure (BP). Next, we used least absolute shrinkage and selection operator (LASSO), a multivariate dimension reduction technique, regression to identify SSB-associated metabolites from a dataset of 938 compounds assayed on an untargeted platform. Finally, we investigated whether the SSB-associated metabolites are also associated with adiposity and metabolic risk. We conducted analyses separately for boys and girls, and accounted for age and pubertal status in all models. Results: Median frequency of SSB intake in this population was 2–4 times per week, with the majority of children consuming sweetened fruit juice or sugar water. In girls, higher SSB intake corresponded with marginally higher BP (Q4 vs. Q1 SSB intake: β = 4.65, 95% CI: −0.22, 9.53 mmHg SBP, P -trend = 0.07). In boys, SSB intake was associated with higher C-peptide (Q4 vs. Q1 SSB intake: β = 0.72, 95% CI: 0.16, 1.27 ng/mL; P -trend = 0.04), C-peptide based insulin resistance (Q4 vs. Q1 SSB intake: β = 0.17, 95 CI: 0.04, 0.30 ng/mL; P -trend = 0.03), and leptin (Q4 vs. Q1 SSB intake: β = 3.78, 95% CI: 0.49, 7.08 ng/mL; P -trend = 0.02). We identified 6 named metabolites in girls (5-methyl-tetrohydroflouride (5-THF), phenylephrine, urate, nonanoate, deoxyuridine, and sn-glycero-3-phosphocholine) and 3 named metabolites in boys (2-piperidinone, octanoylcarnitine, catechol) correlated with SSB intake. In girls, urate and nonanoate marked the relationship of SSB intake with blood pressure Conclusions: Urate and nonanoate may mark the association of SSB intake with higher BP in peripubertal girls. Future prospective studies are required to confirm our findings. Funding Sources: P01ES022844 from the National Institute for Environmental Health Sciences (NIEHS); RD83543601 from the US Environmental Protection Agency (US EPA), Michigan Nutrition Obesity Research Center (P30 DK089503) and Michigan Regional Comprehensive Metabolomics Resource Core (R24 DK097153); the Robert C. and Veronica Atkins Foundation.