Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages. Issue 54 (2nd October 2019)

• Record Type: Journal Article
• Authors: Liu, Jie; Wang, Huailing; Wang, Guangjun; Luo, Qiang; Cao, Hui; Liu, Xiaoyu; Zhang, Zehuang; Yang, Pingchang; Liu, Zhigang
• Is Part Of: RSC advances. Volume 9:Issue 54(2019)
• Page Start: 31296
• Page End: 31305
• Publication Date: 2019-10-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c9ra06284j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Locusts are esteemed as a traditional Chinese medicine, as well as tonic foods in Asian countries. Abstract : Locusts are esteemed as a traditional Chinese medicine, as well as tonic foods in Asian countries. While searching for natural anti-inflammatory agents in natural products, we isolated four novel locust cyclopeptides (LCPs) and the results show that [cyclo-(Trp-Leu-His-Thr)]∼LCP-3 has potent anti-inflammatory potency in RAW264.7 and HMC-1 cells under LPS (lipopolysaccharide) stimuli. Furthermore, mechanistic studies show that LCP-3 attenuates pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, NO and PGE2) expression. Moreover, LCP-3 attenuates inflammatory damage associated with the direct inhibition of iNOS and COX-2 expression. LCP-3 also regulates the MAPK, PI3K/AKT and NF-κB pathways to attenuate LPS-induced damage. Of note, our study first reports the anti-inflammatory potency of LCPs and elucidates their underlying molecular mechanisms.