Cucurbit[7]uril-anchored polymer vesicles enhance photosensitization in the nucleus. Issue 39 (16th September 2019)

• Record Type: Journal Article
• Authors: Xiao, Bo; Wang, Qi; Zhang, Sheng; Li, Xiao-Yu; Long, Shi-Qi; Xiao, Yan; Xiao, Song; Ni, Xin-Long
• Is Part Of: Journal of materials chemistry. Volume 7:Issue 39(2019)
• Page Start: 5966
• Page End: 5971
• Publication Date: 2019-09-16
• Subjects: Materials -- Periodicals; Chemistry, Analytic -- Periodicals; Biomedical materials -- Research -- Periodicals; 543.0284
• DOI: 10.1039/c9tb01526d
• Languages: English
• ISSNs: 2050-750X

Abstract

Abstract : Q[7] polymer based vesicles, as a PS loading vehicle, demonstrated highly enhanced photosensitization and efficient anticancer effects via entering the nuclei of the cancer cells. Abstract : Effective photosensitizers (PSs) are highly desirable in many applications, such as photodynamic therapy and catalytic chemistry. Here, we demonstrated that vesicles of cucurbit[7]uril (Q[7] or CB[7])-anchored polymers enhanced photosensitization in the nucleus. The polyacrylic acid chain spacer triggered Q[7] polymers on the surfaces of the vesicles at a regular distance, thus not only leading to efficient inhibition of the aggregation induced self-quenching of the porphyrin based cationic PS in aqueous solution but also maintaining the PS at high concentration on the nanoscale via stable host–guest interactions. Further experiments indicated that Q[7] polymer based vesicles as a PS loading vehicle had a high penetration depth, entering the nuclei of cancer cells. Therefore, highly enhanced photosensitization and efficient anticancer effects were achieved.