DMF/NaOH/H2O: a metal-free system for efficient and chemoselective reduction of α-ketoamides. Issue 20 (11th September 2019)

• Record Type: Journal Article
• Authors: Ye, Rongcong; Hao, Feiyue; Liu, Guyue; Zuo, Qingsong; Deng, Lijun; Jin, Zhengneng; Wu, Jiashou
• Is Part Of: Organic chemistry frontiers. Volume 6:Issue 20(2019)
• Page Start: 3562
• Page End: 3565
• Publication Date: 2019-09-11
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/c9qo00842j
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A metal-free method for efficient and chemoselective reduction of α-ketoamides using DMF/NaOH/H2 O system has been developed. Abstract : We have developed a transition metal free method for efficient and chemoselective reduction of CO bonds using DMF as a hydrogen source and solvent. α-Ketoamides bearing various functional groups are smoothly reduced to α-hydroxyamides in high yields with the present DMF/NaOH/H2 O reduction system.