Intercepted dehomologation of aldoses by N-heterocyclic carbene catalysis – a novel transformation in carbohydrate chemistry. Issue 81 (19th September 2019)

• Record Type: Journal Article
• Authors: Draskovits, Markus; Kalaus, Hubert; Stanetty, Christian; Mihovilovic, Marko D.
• Is Part Of: Chemical communications. Volume 55:Issue 81(2019)
• Page Start: 12144
• Page End: 12147
• Publication Date: 2019-09-19
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1039/c9cc05906g
• Languages: English
• ISSNs: 1359-7345

Abstract

Abstract : Examples of strong substrate governance and tuning of selectivity between two borderline scenarios by successful catalyst design are reported. Abstract : The development of an N-heterocyclic carbene (NHC) catalysed intercepted dehomologation of aldoses is reported. The unique selectivity of NHCs for aldehydes is exploited in the complex context of reducing sugars. Examples of strong substrate governance for either intercepted dehomologation or a subsequent redox-lactonisation were identified and mechanistically understood. More importantly, it was shown that catalyst design allowed the tuning of the selectivity of the reaction with structurally unbiased starting materials towards either of the two scenarios.